Arylaminoethyl amides as inhibitors of the cysteine protease cathepsin K-investigating P1' substituents

Bioorg Med Chem Lett. 2003 Jun 16;13(12):1997-2001. doi: 10.1016/s0960-894x(03)00344-5.

Abstract

Modeling, synthesis and in vitro activities of a series of arylaminoethyl amide based inhibitors of the cysteine protease cathepsin K are described.

MeSH terms

  • Amides / chemical synthesis
  • Amides / chemistry*
  • Amides / pharmacology*
  • Benzene Derivatives / chemistry
  • Benzene Derivatives / pharmacology
  • Binding Sites
  • Cathepsin K
  • Cathepsin L
  • Cathepsins / antagonists & inhibitors*
  • Cysteine Endopeptidases
  • Cysteine Proteinase Inhibitors / chemical synthesis
  • Cysteine Proteinase Inhibitors / chemistry*
  • Cysteine Proteinase Inhibitors / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Models, Molecular
  • Recombinant Proteins / antagonists & inhibitors
  • Structure-Activity Relationship

Substances

  • Amides
  • Benzene Derivatives
  • Cysteine Proteinase Inhibitors
  • Recombinant Proteins
  • Cathepsins
  • Cysteine Endopeptidases
  • CTSL protein, human
  • Cathepsin L
  • cathepsin S
  • CTSK protein, human
  • Cathepsin K